Toxicity and effect of whitening toothpastes on enamel surface

This in vitro study evaluated the biocompatibility and abrasivity of whitening conventional toothpastes. Samples (non-whitening) - Edel White Infant (EWI) toothpastes Whitening (EWW), CAREFORTE (EWC), Colgate Total 12 Ò Professional (C), Oral-B (OB) were dissolved culture medium (0.2 g sample weight per mL). Human gingival fibroblasts (hGF) placed contact with different dilutions media that had been previously exposed to these Cytotoxicity was then assessed using methyl tetrazolium test (MTT) cell survival rate determined. Genotoxicity by micronucleus (MNT) number micronuclei determined before after exposure toothpaste solutions. The enamel surface roughness specimens bovine teeth (n = 10 group) 10,000 brushing cycles, investigated results statistically analyzed Mann-Whitney U two-way ANOVA (p < 0.05). According MTT assay, EWW OB presented significant cytotoxicity 0.01), but no genotoxic effects > C significantly abrasive 0.01). findings this may be helpful for individualized selection commercial toothpastes, as some present cause changes.